Impact of Rare Bleeding Disorders during Pregnancy on Maternal and Fetal Outcomes: Review of 29 Pregnancies at a Single Center

ABSTRACT podocarpus gracilior column Objective: This study aims to give information about the relationship between different types of factor deficiencies and maternal/obstetric outcomes.Methods We retrospectively reviewed the medical records of eight women with factor deficiency disorders.The demographic and clinical features of the patients after their last pregnancies were registered retrospectively.Results: There were 29 pregnancies among the 8 patients.

The spontaneous abortion rate was relatively high in two patients with factor XIII deficiency (80% and 57.1%) compared with the other factor deficiency groups.There were 16 births, which included 1 set of twins, and 2 deaths (1 stillbirth and 1 postpartum exitus occurred in the same patient).Intrauterine growth restriction was noted in five cases; four of these occurred in factor X deficiency cases.

The mean decrease in hemoglobin level of tech lighting tellium all patients after birth was 1.7 g/dL (range, 0.2-3.6 g/dL).

Red blood cell transfusion was required only in one case of factor XIII deficiency.Conclusions: There is currently no consensus on the pregnancy management of women with factor deficiencies because of the limited knowledge due to the rarity of such disorders.Labor should be managed in a dedicated unit with a team consisting of an obstetrician, a hematologist, an anesthesiologist, a midwife, and a pediatrician to minimalize the complications.

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